Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | CCNK | O75909 | 7/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | NRAS | P01111 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23292348 | 1.00 | MAPK8 (0.54) | MAPK8CCNKCDK12CDK7CCNH | |
| Hydrochloric Acid SCHEMBL23292386 | 0.92 | IKBKB (0.55) | MAPK8CCNKCDK12CDK7CCNH | |
| Hydrochloric Acid SCHEMBL23292382 | 0.92 | IKBKB (0.55) | MAPK8CCNKCDK12CDK7CCNH | |
| SCHEMBL29424380 | 0.82 | CDK2 (0.51) | MAPK8CCNKCDK12CDK7CCNH | |
| SCHEMBL30565323 | 0.81 | PRKCZ (0.52) | CCNKCDK12CDK2CCNT1CCNE1 | |
| SCHEMBL23292393 | 0.80 | MKNK1 (0.58) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL13039388 | 0.77 | CDK1 (0.50) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL31666547 | 0.76 | CCNK (0.71) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL31666542 | 0.76 | CCNK (0.71) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL13524818 | 0.75 | BRD4 (0.52) | CCNKCDK12CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3813819-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-112638373-A | Cyclin-dependent kinase inhibitors | 金耐特生物制药公司 | 2021-04-09 | — | — | CN | disclosed |