Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330185 | 1.00 | REN (0.40) | RENCYP3A4MEN1KMT2ABRD4 | |
| SCHEMBL2360935 | 1.00 | REN (0.40) | RENCYP3A4MEN1KMT2ABRD4 | |
| SCHEMBL3337128 | 1.00 | REN (0.40) | RENCYP3A4MEN1KMT2ABRD4 | |
| SCHEMBL2360982 | 1.00 | REN (0.40) | RENCYP3A4MEN1KMT2ABRD4 | |
| SCHEMBL26126004 | 0.84 | CNR2 (0.32) | RENCYP3A4 | |
| SCHEMBL2996749 | 0.84 | CNR2 (0.32) | RENCYP3A4 | |
| SCHEMBL3615805 | 0.84 | CNR2 (0.32) | RENCYP3A4 | |
| SCHEMBL4975133 | 0.84 | CNR2 (0.32) | RENCYP3A4 | |
| SCHEMBL3615804 | 0.84 | CNR2 (0.32) | RENCYP3A4 | |
| SCHEMBL1860873 | 0.84 | MEN1 (0.46) | RENMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-B1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS INC (US) | 2011-08-17 | — | — | EP | claimed |
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |