Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.61 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.59 |
| ▸ | GALR3 | O60755 | 3/20 | 0.58 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20242949 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL9274775 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL31066875 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL2943250 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL17053182 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL31066882 | 0.93 | TLR8 (0.70) | LMNAHTTTP53PKMP2RX7 | |
| SCHEMBL8273589 | 0.92 | LMNA (0.61) | LMNAHTTTP53PKMTNF | |
| Hydrochloric Acid SCHEMBL8158771 | 0.92 | TLR8 (0.68) | LMNAHTTTP53PKMTLR8 | |
| SCHEMBL6446137 | 0.90 | LMNA (0.69) | LMNAHTTTP53PKMTNF | |
| SCHEMBL11197015 | 0.90 | LMNA (0.67) | LMNAHTTTP53PKMTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | WASHINGTON UNIVERSITY (US) | 2025-03-11 | — | — | US | disclosed |
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20200283820-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| WO-2011098829-A1 | NUCLEIC ACID COMPLEXES | PROCARTA BIOSYSTEMS LTD (GB) | 2011-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | LMNA 3303/4885HTT 3165/4885TP53 1377/4885 |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | NADK, NAPRT, TIPARP | LMNA 3303/4885HTT 3165/4885TP53 1377/4885 |
| US-20200283820-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | LMNA 3303/4885HTT 3165/4885TP53 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.