Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.82 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.74 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.74 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.74 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330736 | 1.00 | F11 (0.82) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2328272 | 0.92 | F11 (0.83) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2328269 | 0.92 | F11 (0.83) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2328198 | 0.90 | F11 (1.00) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2331259 | 0.90 | F11 (1.00) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2324090 | 0.90 | F11 (0.81) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2323976 | 0.89 | F11 (0.84) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2326061 | 0.88 | F11 (0.88) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2331022 | 0.88 | F11 (0.88) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL2325350 | 0.88 | F11 (0.88) | F11KLKB1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773775-B1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-08-17 | — | — | EP | claimed |