SCHEMBL2331411

SCHEMBL2331411

C[Bi](C)C(C)(C)c1ccc(C(=O)Oc2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.62
TDP1 Q9NUW8 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.49
PARP10 Q53GL7 1/20 0.49
KMT2A Q03164 4/20 0.48
MEN1 O00255 3/20 0.48
PRSS1 P07477 2/20 0.48
ACR P10323 2/20 0.48
TMPRSS15 P98073 2/20 0.48
ALDH1A1 P00352 4/20 0.46
PKM P14618 1/20 0.46
NSD2 O96028 1/20 0.45
THRB P10828 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ELANE P08246 1/20 0.43
TNF P01375 1/20 0.41
KLF5 Q13887 1/20 0.41
NOD1 Q9Y239 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL678424 0.83 MAPT (0.70) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL1790578 0.83 MAPT (0.87) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL28679086 0.82 MAPT (0.84) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL548358 0.82 MAPT (0.68) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL5706144 0.82 MAPT (0.68) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL3180097 0.81 MAPT (0.66) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL27705933 0.81 MAPT (0.66) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL677036 0.81 MAPT (0.66) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL11682889 0.80 MAPT (0.69) MAPTTDP1L3MBTL1SMN1; SMN2PARP10
SCHEMBL70034 0.79 PARP10 (0.70) MAPTTDP1L3MBTL1SMN1; SMN2PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2133357-B1 LIVING RADICAL POLYMERIZATION PROMOTER OTSUKA CHEMICAL CO LTD (JP) 2016-11-16 EP disclosed
US-8076430-B2 Living radical polymerization promoter OTSUKA CHEMICAL CO., LTD. (JP) 2011-12-13 US disclosed
EP-1829883-B1 ORGANIC BISMUTH COMPOUND, METHOD FOR PRODUCING SAME, LIVING RADICAL POLYMERIZATION INITIATOR, METHOD FOR PRODUCING POLYMER USING SAME, AND POLYMER OTSUKA CHEMICAL CO LTD (JP) 2011-08-17 EP disclosed
US-7847043-B2 Organic bismuth compound, method for producing same, living radical polymerization initiator, method for producing polymer using same, and polymer OTSUKA CHEMICAL CO., LTD. (JP) 2010-12-07 US disclosed
US-20100022728-A1 LIVING RADICAL POLYMERIZATION PROMOTER OTSUKA CHEMICAL CO., LTD. (JP) 2010-01-28 US disclosed
EP-2133357-A1 LIVING RADICAL POLYMERIZATION PROMOTER Otsuka Chemical Holdings Co., Ltd. (JP) 2009-12-16 EP disclosed
US-20070265404-A1 Organic Bismuth Compound, Method for Producing Same, Living Radical Polymerization Initiator, Method for Producing Polymer Using Same, and Polymer OTSUKA CHEMICAL CO., LTD. (JP) 2007-11-15 US disclosed
EP-1829883-A1 ORGANIC BISMUTH COMPOUND, METHOD FOR PRODUCING SAME, LIVING RADICAL POLYMERIZATION INITIATOR, METHOD FOR PRODUCING POLYMER USING SAME, AND POLYMER Otsuka Chemical Co., Ltd. (JP) 2007-09-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070265404-A1 Organic Bismuth Compound, Method for Producing Same, Living Radical Polymerization Initiator, Method for Producing Polymer Using Same, and Polymer DOHH, COASY, ODC1 MAPT 3794/4885TDP1 3585/4885L3MBTL1 674/4885
US-20100022728-A1 LIVING RADICAL POLYMERIZATION PROMOTER DNMT1, CYP1B1, DNMT3B MAPT 4496/4885TDP1 1393/4885L3MBTL1 342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.