Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | GLA | P06280 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | MIF | P14174 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18583390 | 0.90 | GLA (0.65) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL23316744 | 0.89 | NPC1 (0.52) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL24046191 | 0.85 | NPC1 (0.62) | NPC1RAB9AKDM4EGLAMIF | |
| SCHEMBL23713535 | 0.83 | RAB9A (0.51) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL18583707 | 0.81 | MIF (0.71) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL23713534 | 0.81 | MIF (0.46) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL18583393 | 0.80 | GLA (0.56) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL18583376 | 0.79 | RAB9A (0.48) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL18583389 | 0.77 | GLA (0.55) | NPC1RAB9AKDM4EGLAKMT2A | |
| SCHEMBL24595686 | 0.77 | MIF (0.42) | NPC1RAB9AKDM4EGLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3583100-B1 | COMPOUNDS CONTAINING SI ATOMS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2021-05-05 | — | — | EP | disclosed |