Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | HTT | P42858 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147702 | 0.84 | KDM4E (0.73) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL13850723 | 0.81 | KDM4E (0.65) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL30037891 | 0.81 | ALDH1A1 (0.61) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL162189 | 0.81 | ALDH1A1 (0.61) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL28431272 | 0.80 | KDM4E (0.62) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| Azapicyl SCHEMBL24931095 | 0.80 | KDM4E (0.68) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL25999794 | 0.79 | KDM4E (0.61) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6385940 | 0.79 | ALDH1A1 (0.59) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29898692 | 0.79 | ALDH1A1 (0.59) | KDM4EHTTLMNAL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1291172 | 0.79 | ALDH1A1 (0.59) | KDM4EHTTLMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128577-A1 | Selective HDAC6 Inhibitors | HDAC6, HDAC1, HDAC3 | KDM4E 308/4885HTT 359/4885LMNA 4062/4885 |
| US-11351178-B2 | Selective HDAC6 inhibitors | HDAC6, HDAC1, HDAC3 | KDM4E 304/4885HTT 346/4885LMNA 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.