Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 15/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | MYLK | Q15746 | 1/20 | 0.41 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23317880 | 0.95 | MAPK14 (0.45) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL23317765 | 0.89 | MAPK1 (0.44) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL23368495 | 0.86 | CTSC (0.40) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL22278820 | 0.85 | MAPK8 (0.43) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL22278819 | 0.81 | ULK1 (0.41) | MAPK1MAPK8MAPK3EGFR | |
| SCHEMBL19686048 | 0.78 | MAPK1 (0.46) | MAPK1MAPK8MAPK3ERN1CDK2 | |
| SCHEMBL22278822 | 0.78 | ULK1 (0.43) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL22278844 | 0.77 | ULK1 (0.43) | — | |
| SCHEMBL13369321 | 0.77 | MAPK8 (0.55) | MAPK1MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL23050289 | 0.76 | MAPK1 (0.43) | MAPK1MAPK14MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158035-A1 | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2023-05-25 | — | — | US | disclosed |
| US-20210128565-A1 | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158035-A1 | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | TPMT, MGMT, TYMP | MAPK1 2129/4885MAPK14 3581/4885MAPK8 1613/4885 |
| US-20210128565-A1 | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | TPMT, MGMT, TYMP | MAPK1 2129/4885MAPK14 3581/4885MAPK8 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.