Sugi Predict

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SCHEMBL23318232

SCHEMBL23318232

CC(C)C(=O)c1cc(C(=O)NC2CC2)cn(Cc2ccccc2)c1=O

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 19/20 0.77
▸ TRIM24 O15164 1/20 0.77
▸ BRD1 O95696 1/20 0.77
▸ CCL2 P13500 1/20 0.77
▸ TAF1 P21675 1/20 0.77
▸ BRD2 P25440 1/20 0.77
▸ SMARCA2 P51531 1/20 0.77
▸ SMARCA4 P51532 1/20 0.77
▸ BRPF1 P55201 1/20 0.77
▸ EP300 Q09472 1/20 0.77
▸ BPTF Q12830 1/20 0.77
▸ CACNA1C Q13936 1/20 0.77
▸ BRD3 Q15059 1/20 0.77
▸ BRDT Q58F21 1/20 0.77
▸ ATAD2 Q6PL18 1/20 0.77
▸ PBRM1 Q86U86 1/20 0.77
▸ TAF1L Q8IZX4 1/20 0.77
▸ CREBBP Q92793 1/20 0.77
▸ KAT2A Q92830 1/20 0.77
▸ KAT2B Q92831 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23318383 0.89 BRD4 (0.83) BRD4TRIM24BRD1CCL2TAF1
Gsk620 SCHEMBL18584671 0.87 BRD4 (1.00) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL18584584 0.86 BRD4 (0.86) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL20494041 0.83 BRD4 (0.92) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL18617026 0.83 BRD4 (0.92) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL18584911 0.83 BRD4 (1.00) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL18616175 0.82 BRD4 (0.90) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL20493953 0.81 BRD4 (0.81) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL20516011 0.81 BRD4 (1.00) BRD4TRIM24BRD1CCL2TAF1
SCHEMBL24311756 0.80 BRD4 (0.69) BRD4TRIM24BRD1CCL2TAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230148299-A1 FEM1B PROTEIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-11 — — US disclosed
US-20230145782-A1 p53 MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-11 — — US disclosed
US-20230145782-A1 p53 MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-11 — — US disclosed
US-20230148299-A1 FEM1B PROTEIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-11 — — US disclosed
WO-2021183431-A1 FEM1B PROTEIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-09-16 — — WO disclosed
WO-2021087096-A1 P53 MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-05-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230148299-A1 FEM1B PROTEIN BINDING AGENTS AND USES THEREOF FEM1B, GSKIP, FNIP1 BRD4 1525/4885TRIM24 88/4885BRD1 1392/4885
US-20230145782-A1 p53 MODULATORS AND USES THEREOF TP53, TP53BP1, MDM2 BRD4 1654/4885TRIM24 437/4885BRD1 1579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.