Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 16/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23280596 | 0.85 | PSMB5 (0.45) | EGLN1MAP4K4GRIN2B | |
| SCHEMBL24011925 | 0.85 | MAP4K4 (0.63) | MAP4K4 | |
| SCHEMBL24011721 | 0.85 | MAP4K4 (0.41) | EGLN1MAP4K4GRIN2B | |
| SCHEMBL23319691 | 0.85 | ESR2 (0.50) | EGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL23319236 | 0.83 | EGLN1 (0.49) | EGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL21613480 | 0.83 | EGLN1 (0.45) | EGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL23319662 | 0.82 | EGLN1 (0.43) | EGLN1GRIN2BGRIN1 | |
| SCHEMBL21613655 | 0.82 | EGLN1 (0.44) | EGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL21613470 | 0.79 | EGLN1 (0.44) | EGLN1MAP4K4GRIN2BGRIN1 | |
| SCHEMBL21613508 | 0.79 | EGLN1 (0.44) | EGLN1MAP4K4GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087144-A1 | THERAPEUTIC METHODS USING VADADUSTAT | AKEBIA THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |