Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.58 |
| ▸ | KAT2B | Q92831 | 6/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.56 |
| ▸ | KAT2A | Q92830 | 5/20 | 0.56 |
| ▸ | EP300 | Q09472 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2084589 | 1.00 | MEN1 (0.64) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL12934212 | 0.90 | MEN1 (0.53) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL2084943 | 0.85 | MEN1 (0.85) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL2084941 | 0.85 | MEN1 (0.85) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL2335243 | 0.83 | KMT2A (0.66) | MEN1KMT2APOLBCTDSP1MAPT | |
| SCHEMBL2085226 | 0.83 | KMT2A (0.66) | MEN1KMT2APOLBCTDSP1MAPT | |
| SCHEMBL5711322 | 0.81 | MEN1 (0.64) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL5711202 | 0.81 | CACNA1B (0.51) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL5711204 | 0.81 | CACNA1B (0.51) | MEN1KMT2APOLBCTDSP1KAT2B | |
| SCHEMBL12934213 | 0.77 | MEN1 (0.68) | MEN1KMT2APOLBCTDSP1KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885717-B1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | MAX DELBRUECK CENTRUM (DE) | 2011-08-17 | — | — | EP | disclosed |
| EP-1885717-A1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006128909-A1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2006-12-07 | — | — | WO | disclosed |
| EP-1728790-A1 | Shp-2 inhibitors, pharmaceutical compositions comprising them and their use for treating phosphatase-mediated diseases | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (DE) | 2006-12-06 | — | — | EP | disclosed |