Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | CKS1B | P61024 | 5/20 | 0.47 |
| ▸ | SKP1 | P63208 | 5/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 5/20 | 0.47 |
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331480 | 0.83 | HRH4 (0.54) | HRH4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL2331484 | 0.80 | HRH4 (0.58) | HRH4PDE10AHCAR2KDM4ENPC1 | |
| SCHEMBL2006084 | 0.79 | DEGS1 (0.51) | CKS1BSKP1SKP2KDM4EMAPT | |
| SCHEMBL21855943 | 0.78 | CKS1B (0.44) | CKS1BSKP1SKP2HCAR2JAK3 | |
| SCHEMBL21855939 | 0.78 | CKS1B (0.44) | CKS1BSKP1SKP2HCAR2JAK3 | |
| SCHEMBL2360815 | 0.73 | HRH4 (0.53) | HRH4PDE10AHCAR2KDM4ENPC1 | |
| SCHEMBL10219394 | 0.73 | HRH4 (0.70) | HRH4PDE10AKDM4ENPC1MAPT | |
| SCHEMBL607451 | 0.73 | HRH4 (1.00) | HRH4KDM4ENPC1MAPTRAB9A | |
| SCHEMBL4334757 | 0.73 | TRPV1 (0.51) | CKS1BSKP1SKP2 | |
| SCHEMBL27629095 | 0.73 | PDE10A (0.53) | HRH4PDE10AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356108-B1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-15 | — | — | EP | disclosed |
| EP-2356108-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055267-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-05-20 | — | — | WO | disclosed |