Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | CKS1B | P61024 | 13/20 | 0.49 |
| ▸ | SKP1 | P63208 | 13/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 13/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728851 | 0.84 | HRH3 (0.58) | HRH4PDE10AP2RX7DGAT1KCNH2 | |
| SCHEMBL2332308 | 0.83 | HRH4 (0.57) | HRH4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL1727907 | 0.80 | DEGS1 (0.56) | PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL2360815 | 0.77 | HRH4 (0.53) | HRH4PDE10ADGAT1KCNH2 | |
| SCHEMBL2331484 | 0.77 | HRH4 (0.58) | HRH4PDE10ADGAT1KCNH2BACE1 | |
| SCHEMBL26969339 | 0.77 | PTGES (0.63) | — | |
| SCHEMBL2331847 | 0.76 | HRH4 (0.52) | HRH4PDE10ADGAT1KCNH2 | |
| SCHEMBL1728774 | 0.75 | HRH3 (0.55) | PDE10ADGAT1KCNH2 | |
| SCHEMBL3650734 | 0.75 | F10 (0.51) | HRH4CKS1BSKP1SKP2P2RX7 | |
| SCHEMBL1728004 | 0.74 | HCAR2 (0.53) | HRH4PDE10ACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356108-B1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-15 | — | — | EP | disclosed |
| EP-2356108-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055267-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-05-20 | — | — | WO | disclosed |