SCHEMBL23323322

SCHEMBL23323322

Cc1c2ccccc2c(/C=N\NC2=NCCN2)c2ccccc12

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 8/20 0.86
ADRA1A P35348 5/20 0.86
CHRM2 P08172 1/20 0.86
HTR1A P08908 1/20 0.86
ADORA3 P0DMS8 1/20 0.86
CHRM1 P11229 1/20 0.86
NQO1 P15559 1/20 0.86
DRD1 P21728 1/20 0.86
ACHE P22303 1/20 0.86
SLC6A2 P23975 1/20 0.86
SLC6A4 P31645 1/20 0.86
OPRM1 P35372 1/20 0.86
DRD3 P35462 1/20 0.86
SLC6A3 Q01959 1/20 0.86
ALKBH5 Q6P6C2 1/20 0.86
HTR6 P50406 1/20 0.57
APOBEC3A P31941 1/20 0.51
APOBEC3G Q9HC16 1/20 0.51
ADRA2C P18825 5/20 0.43
ADRA2B P18089 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bisantrene SCHEMBL7472 0.93 ADRA2A (1.00) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL7207049 0.93 ADRA2A (1.00) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL8906393 0.93 ADRA2A (1.00) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL29398210 0.93 ADRA2A (1.00) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL2852448 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL4773 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL1649622 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL17819003 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL17819004 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3
Bisantrene SCHEMBL29665174 0.92 ADRA2A (0.97) ADRA2AADRA1ACHRM2HTR1AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3816157-B1 9-BENZENESULFONIC ACID-10-IMIDAZOLYLANTHRAHYDRAZONE AND SYNTHESIS METHOD AND APPLICATION THEREOF UNIV GUANGXI NORMAL (CN) 2022-07-13 EP disclosed
EP-3816157-A1 9-BENZENESULFONIC ACID-10-IMIDAZOLYLANTHRAHYDRAZONE AND SYNTHESIS METHOD AND APPLICATION THEREOF Guangxi Normal University (CN) 2021-05-05 EP disclosed