Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 7/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20314854 | 0.82 | TEAD1 (0.34) | JAK3TEAD1BTK | |
| SCHEMBL20334548 | 0.81 | TEAD1 (0.34) | JAK3TEAD1 | |
| SCHEMBL23583943 | 0.81 | TEAD1 (0.34) | JAK3TEAD1BTK | |
| SCHEMBL18426888 | 0.80 | CHRM1 (0.33) | — | |
| SCHEMBL27031169 | 0.80 | CHRM1 (0.33) | — | |
| SCHEMBL21610085 | 0.79 | JAK3 (0.34) | JAK3TEAD1BTK | |
| SCHEMBL23735765 | 0.79 | TET3 (0.34) | JAK3TEAD1BTK | |
| SCHEMBL22970007 | 0.77 | CHRM1 (0.42) | JAK3BTK | |
| SCHEMBL22704583 | 0.77 | CHRM1 (0.42) | JAK3BTK | |
| SCHEMBL20334409 | 0.77 | JAK3 (0.33) | JAK3TEAD1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2021086833-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2021-05-06 | — | — | WO | disclosed |