Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569286 | 0.80 | PIK3CD (0.55) | CYP2C19SMN1; SMN2TP53ALDH1A1PIK3CD | |
| SCHEMBL25953833 | 0.80 | CYP2C19 (0.39) | CYP2C19SMN1; SMN2TP53ALDH1A1HTR1A | |
| SCHEMBL23323952 | 0.78 | HRH3 (0.38) | CYP2C19ALDH1A1HTR1APIK3CDHRH3 | |
| SCHEMBL25736046 | 0.77 | CARM1 (0.48) | CYP2C19SMN1; SMN2TP53ALDH1A1MEN1 | |
| SCHEMBL22152624 | 0.76 | KDM4E (0.44) | ALDH1A1HTR1APIK3CD | |
| SCHEMBL15160801 | 0.76 | CYP2C19 (0.47) | CYP2C19SMN1; SMN2TP53ALDH1A1PIK3CD | |
| SCHEMBL25910374 | 0.75 | HTR1A (0.45) | CYP2C19ALDH1A1HTR1APIK3CDHRH3 | |
| SCHEMBL25908071 | 0.74 | HRH3 (0.36) | CYP2C19ALDH1A1HTR1APIK3CDHRH3 | |
| SCHEMBL25909255 | 0.74 | HRH3 (0.36) | CYP2C19ALDH1A1HTR1APIK3CDHRH3 | |
| SCHEMBL25906114 | 0.74 | HRH3 (0.36) | CYP2C19ALDH1A1HTR1APIK3CDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234929-A1 | RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| US-11566007-B2 | Ras inhibitors | Revolution Medicines, Inc. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210130303-A1 | RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566007-B2 | Ras inhibitors | KRAS, NRAS, HRAS | CYP2C19 3930/4885SMN1; SMN2 3728/4885TP53 9/4885 |
| US-20230234929-A1 | RAS INHIBITORS | KRAS, NRAS, HRAS | CYP2C19 3930/4885SMN1; SMN2 3728/4885TP53 9/4885 |
| US-20210130303-A1 | RAS INHIBITORS | KRAS, NRAS, HRAS | CYP2C19 3930/4885SMN1; SMN2 3728/4885TP53 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.