Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381668 | 0.86 | GSK3B (0.60) | GSK3BCDK1CDK2MAPK1GSK3A | |
| SCHEMBL1461697 | 0.84 | GSK3B (0.82) | GSK3BCDK1CDK2MAPK1GSK3A | |
| SCHEMBL2334015 | 0.80 | GSK3B (0.50) | GSK3BCDK1CDK2MAPK1GSK3A | |
| SCHEMBL4392816 | 0.80 | GSK3B (0.61) | GSK3BCDK1CDK2NTRK1MAPK1 | |
| SCHEMBL2338792 | 0.79 | GSK3B (0.49) | GSK3BCDK1CDK2MAPK1GSK3A | |
| SCHEMBL4486223 | 0.78 | GSK3B (0.73) | GSK3BCDK1CDK2NTRK1MAPK1 | |
| SCHEMBL2333341 | 0.76 | GSK3B (0.53) | GSK3BCDK1CDK2MAPK1POLB | |
| SCHEMBL1377235 | 0.75 | GSK3B (0.52) | GSK3BCDK1CDK2KDM4EPOLB | |
| SCHEMBL4392791 | 0.73 | GSK3B (0.76) | GSK3BCDK1CDK2MAPK1GSK3A | |
| SCHEMBL2337608 | 0.73 | GSK3B (0.49) | GSK3BCDK1CDK2KDM4EGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572200-B1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-08-17 | — | — | EP | disclosed |
| EP-1572200-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004062662-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | WO | disclosed |