Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 5/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720248 | 0.87 | TMIGD3 (0.43) | TMIGD3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL2334879 | 0.85 | ADORA1 (0.39) | TMIGD3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL1664988 | 0.82 | ADORA1 (0.43) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL2332219 | 0.78 | ADORA2A (0.51) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6950039 | 0.78 | FDPS (0.40) | ADORA2AADORA1ADORA2B | |
| SCHEMBL27734468 | 0.76 | TMIGD3 (1.00) | TMIGD3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL22571186 | 0.75 | TMIGD3 (0.81) | TMIGD3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL17933852 | 0.72 | ADORA2A (0.74) | TMIGD3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL5057753 | 0.71 | FDPS (0.39) | KMT2AHDAC1 | |
| SCHEMBL1668849 | 0.71 | CSF1R (0.38) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178533-B2 | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses | UCB PHARMA, S.A. (BE) | 2012-05-15 | — | — | US | claimed |
| EP-3610890-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | The Johns Hopkins University (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |