Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 15/20 | 0.57 |
| ▸ | PRKD2 | Q9BZL6 | 7/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23328171 | 1.00 | PRKCZ (0.57) | PRKCZPRKD2BRD4ATAD2ABL1 | |
| SCHEMBL30175652 | 1.00 | PRKCZ (0.57) | PRKCZPRKD2BRD4ATAD2ABL1 | |
| SCHEMBL23328179 | 1.00 | PRKCZ (0.57) | PRKCZPRKD2BRD4ATAD2ABL1 | |
| SCHEMBL30175633 | 1.00 | PRKCZ (0.57) | PRKCZPRKD2BRD4ATAD2ABL1 | |
| SCHEMBL23328117 | 0.94 | PRKCZ (0.62) | PRKCZPRKD2BRD4 | |
| SCHEMBL30175611 | 0.94 | PRKCZ (0.62) | PRKCZPRKD2BRD4 | |
| SCHEMBL23328379 | 0.94 | PRKCZ (0.62) | PRKCZPRKD2BRD4 | |
| SCHEMBL23328115 | 0.94 | PRKCZ (0.62) | PRKCZPRKD2BRD4 | |
| SCHEMBL23301264 | 0.94 | PRKCZ (0.49) | PRKCZPRKD2BRD4ATAD2ABL1 | |
| SCHEMBL29897396 | 0.94 | PRKCZ (0.49) | PRKCZPRKD2BRD4ATAD2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021084265-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2021-05-06 | — | — | WO | disclosed |
| WO-2021084264-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2021-05-06 | — | — | WO | disclosed |