SCHEMBL23328219

SCHEMBL23328219

CSc1c(C)cccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.38
CYP1A2 P05177 3/20 0.36
CYP2A6 P11509 2/20 0.36
TRPA1 O75762 1/20 0.36
GAA P10253 2/20 0.35
MAPT P10636 4/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 2/20 0.35
LMNA P02545 2/20 0.35
ACHE P22303 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
SCN4A P35499 2/20 0.34
NPSR1 Q6W5P4 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5594805 0.85 CYP1A2 (0.43) ALDH1A1CYP1A2CYP2A6MAPTSMN1; SMN2
SCHEMBL9264116 0.83 ALDH1A1 (0.39) ALDH1A1CYP1A2CYP2A6TRPA1GAA
SCHEMBL4460481 0.82 CYP2A6 (0.45) ALDH1A1CYP1A2CYP2A6TRPA1SMN1; SMN2
SCHEMBL9264123 0.79 ALDH1A1 (0.37) ALDH1A1CYP1A2CYP2A6TRPA1GAA
SCHEMBL3788212 0.76 MAPT (0.43) ALDH1A1CYP1A2CYP2A6MAPTSMN1; SMN2
SCHEMBL11614308 0.75
SCHEMBL21027359 0.74 CYP1A2 (0.35) ALDH1A1CYP1A2CYP2A6MAPTSMN1; SMN2
SCHEMBL21828962 0.74 CYP1A2 (0.35) ALDH1A1CYP1A2CYP2A6MAPTSMN1; SMN2
SCHEMBL3781780 0.74 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2A6SMN1; SMN2TSHR
SCHEMBL29929127 0.74 CYP1A2 (0.35) ALDH1A1CYP1A2CYP2A6MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023218195-A1 GCN2 INHIBITORR IP2IPO INNOVATIONS LIMITED (GB) 2023-11-16 WO disclosed
EP-3481830-B1 BICYCLIC UREA KINASE INHIBITORS AND USES THEREOF BROAD INST INC (US) 2022-02-16 EP disclosed
WO-2021250399-A1 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO INNOVATIONS LIMITED (GB) 2021-12-16 WO disclosed
WO-2021084265-A1 ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-06 WO disclosed