Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944804 | 0.84 | ADORA2B (0.51) | ADORA2BADORA2AADORA3ALDH1A1ADORA1 | |
| SCHEMBL2332902 | 0.84 | ADORA2B (0.48) | ADORA2BADORA2AADORA3ALDH1A1ADORA1 | |
| SCHEMBL1945205 | 0.83 | ADORA2B (0.59) | ADORA2BADORA2AADORA3ALDH1A1ADORA1 | |
| SCHEMBL12223729 | 0.82 | ADORA2B (0.48) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1945927 | 0.82 | ADORA2B (0.48) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL12245132 | 0.81 | ADORA2A (0.55) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1944307 | 0.80 | ADORA2B (0.52) | ADORA2BADORA2AADORA3ALDH1A1ADORA1 | |
| SCHEMBL1944309 | 0.79 | ADORA2B (0.50) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1947373 | 0.78 | ADORA2B (0.52) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1061950 | 0.76 | ADORA2A (0.53) | ADORA2BADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444233-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | GILEAD PALO ALTO INC (US) | 2011-08-17 | — | — | EP | disclosed |