Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Proparacaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 4/20 | 1.00 |
| ▸ | SCN2A known ✓ | Q99250 | 4/20 | 1.00 |
| ▸ | SCN3A known ✓ | Q9NY46 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | MAOA | P21397 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proparacaine SCHEMBL29805494 | 1.00 | CYP2D6 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL9872795 | 0.99 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL30675347 | 0.99 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL93880 | 0.99 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL23333 | 0.99 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL20641500 | 0.95 | CYP2D6 (0.91) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL11131964 | 0.94 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL9419527 | 0.94 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Betoxycaine SCHEMBL25758 | 0.87 | CYP2D6 (0.77) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL10981263 | 0.87 | CYP2D6 (0.76) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14213 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144801-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-05-28 | — | — | US | claimed |
| US-20260137637-A1 | ANESTHETIC AGENT MICRO AND NANO PARTICLES, AND METHODS OF MAKING AND USING THE SAME | HAAS ERIC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4743122-A1 | THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES | The Johns Hopkins University (US) | 2026-05-20 | — | — | EP | claimed |
| US-12622873-B2 | Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2026-05-12 | — | — | US | claimed |
| US-20260115156-A1 | INJECTABLE COMPOSITION INCLUDING HYDROGEL CONTAINING ANESTHETIC AGENT | UNIV KOREA RES & BUS FOUND (KR) | 2026-04-30 | — | — | US | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260083666-A1 | METHOD OF TREATING DISEASE | CREWS THOMAS M (US) | 2026-03-26 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| EP-4436552-B1 | GASTRO-RETENTIVE ORAL DOSAGE UNIT CONTAINING A LOCAL ANAESTHETIC | OREXA B V (NL) | 2026-02-04 | — | — | EP | claimed |
| US-4938970-A | Irrigation of wound, injection, opthalmic solution | HUSTEAD SOLUTION COMPANY, THE | 1990-07-03 | — | — | US | claimed |
| US-4597965-A | Method and composition for controlling corneal hydration | HOLLES LABORATORIES, INC. (US) | 1986-07-01 | — | — | US | claimed |
| US-4495174-A | TIME-RELEASE AGENTS | RESEARCH CORPORATION (US) | 1985-01-22 | — | — | US | claimed |
| EP-0029844-A1 | METHOD AND COMPOSITION FOR CONTROLLING CORNEAL HYDRATION. | HOLLES LAB INC (US) | 1981-06-10 | — | — | EP | claimed |
| US-4271144-A | AQUEOUS SOLUTION, HYDROPHILIC, HIGH MOLECULAR WEIGHT, NONVISCOUS | HOLLES LABORATORIES, INC. (US) | 1981-06-02 | — | — | US | claimed |
| EP-0029844-A4 | METHOD AND COMPOSITION FOR CONTROLLING CORNEAL HYDRATION. | HOLLES LAB INC (US) | 1981-05-15 | — | — | EP | claimed |
| WO-1980002643-A1 | METHOD AND COMPOSITION FOR CONTROLLING CORNEAL HYDRATION | HOLLES LAB INC (US) | 1980-12-11 | — | — | WO | claimed |
| US-4041174-A | INJECTING AN ESTER LOCAL ANESTHETIC | ROM-AMER PHARMACEUTICALS, LTD. (US) | 1977-08-09 | — | — | US | claimed |
| US-4029794-A | SAXITOXIN | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-06-14 | — | — | US | claimed |
| US-4022899-A | TETRODOXIN, DESOXYTETRODOXIN, AMINOALKYL BENZOATE | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-05-10 | — | — | US | claimed |