Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Proparacaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 4/20 | 0.98 |
| ▸ | SCN2A known ✓ | Q99250 | 4/20 | 0.98 |
| ▸ | SCN3A known ✓ | Q9NY46 | 4/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.98 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.98 |
| ▸ | MAOA | P21397 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.98 |
| ▸ | RAD52 | P43351 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HTR3A | P46098 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proparacaine SCHEMBL23333 | 1.00 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL9872795 | 1.00 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL30675347 | 1.00 | CYP2D6 (0.98) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL29805494 | 0.99 | CYP2D6 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL23334 | 0.99 | CYP2D6 (1.00) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL20641500 | 0.96 | CYP2D6 (0.91) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL9419527 | 0.95 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL11131964 | 0.95 | CYP2D6 (0.89) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Proparacaine SCHEMBL10981263 | 0.88 | CYP2D6 (0.76) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 | |
| Betoxycaine SCHEMBL25758 | 0.86 | CYP2D6 (0.77) | CYP2D6SCN1ASCN2ASCN3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3771 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260013482-A1 | METHOD FOR CONSTRUCTING AN ANIMAL MODEL OF OPEN-ANGLE GLAUCOMA | THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY (CN) | 2026-01-15 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250186334-A1 | TOPICAL OCULAR THERAPY | Moxicaine, LLC (US) | 2025-06-12 | — | — | US | claimed |
| US-20250186424-A1 | CORNEAL THERAPY | HARROW IP, LLC | 2025-06-12 | — | — | US | claimed |
| CN-119969338-A | Construction method of ocular hypertension animal model | 中南大学湘雅二医院 | 2025-05-13 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119454573-A | Preparation method of temperature-sensitive hydrogel and method for constructing chronic glaucoma model | 中南大学湘雅二医院 | 2025-02-18 | — | — | CN | claimed |
| CN-119317363-A | Modulation of oral microbiota in periodontal disease | 玛氏公司 | 2025-01-14 | — | — | CN | claimed |
| CN-119235782-A | Alternib hydrochloride suspension and preparation method thereof | 常州市武进人民医院(常州市第八人民医院) | 2025-01-03 | — | — | CN | claimed |
| US-5626865-A | Enzyme-orthokeratology | ADVANCED CORNEAL SYSTEMS, INC. (US) | 1997-05-06 | — | — | US | claimed |
| WO-1997007793-A1 | FORMULATIONS OF HALOALKYLAMINES AND LOCAL ANAESTHETICS AND METHODS FOR THE TREATMENT OF REFLEX SYMPATHETIC DYSTROPHY (RSD) | NEW YORK MEDICAL COLLEGE (US) | 1997-03-06 | — | — | WO | claimed |
| WO-1997006782-A1 | COMPOSITIONS INCLUDING O-CARBOXYALKYL CHITOSAN AND METHODS OF USE IN OPHTHALMICS | NOVARTIS AG (CH) | 1997-02-27 | — | — | WO | claimed |
| WO-1997000669-A1 | COMPOSITIONS AND METHODS FOR STABILIZING POLYMERS | NOVARTIS AG (CH) | 1997-01-09 | — | — | WO | claimed |
| EP-0608341-A1 | ENZYME-ORTHOKERATOLOGY | ADVANCED CORNEAL SYSTEMS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| US-5270051-A | Enzyme-orthokeratology | ISTA PHARMACEUTICALS, INC. | 1993-12-14 | — | — | US | claimed |
| WO-1993007840-A1 | ENZYME-ORTHOKERATOLOGY | ADVANCED CORNEAL SYSTEMS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0126684-B1 | DRUG DELIVERY SYSTEM UTILIZING THERMOSETTING GELS | MERCK & CO. INC. (US) | 1991-08-28 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4474751-A | SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |