Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | RXRA | P19793 | 6/20 | 0.43 |
| ▸ | RXRB | P28702 | 6/20 | 0.43 |
| ▸ | RXRG | P48443 | 6/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337994 | 0.93 | HDAC6 (0.43) | HDAC1HDAC6HDAC8HDAC5LTB4R2 | |
| SCHEMBL2341767 | 0.88 | LPAR1 (0.44) | RXRARXRBRXRGMAPTLPAR1 | |
| SCHEMBL1286656 | 0.87 | LPAR1 (0.48) | RXRARXRBRXRGMAPTLPAR1 | |
| SCHEMBL2761502 | 0.87 | HDAC1 (0.40) | HDAC1HDAC6HDAC8HDAC5LTB4R2 | |
| SCHEMBL2338529 | 0.87 | LPAR1 (0.44) | RXRARXRBRXRGMAPTLPAR1 | |
| SCHEMBL9998264 | 0.86 | LPAR1 (0.48) | RXRARXRBRXRGMAPTLPAR1 | |
| SCHEMBL1247195 | 0.86 | HDAC1 (0.43) | HDAC1HDAC6HDAC8RXRARXRB | |
| SCHEMBL2761307 | 0.85 | MAPT (0.37) | HDAC1HDAC6HDAC8HDAC5LTB4R2 | |
| SCHEMBL2761437 | 0.85 | HDAC1 (0.41) | HDAC1HDAC6HDAC8HDAC5LTB4R2 | |
| SCHEMBL2635830 | 0.85 | LPAR1 (0.42) | HDAC1HDAC6HDAC8HDAC5LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | claimed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |