SCHEMBL2333922

SCHEMBL2333922

Cc1nc(C(=O)Nc2cnn(Cc3cnc(C(C)O)o3)n2)c(-c2cccc(F)c2)o1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 19/20 0.63
CACNA1H O95180 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2328917 0.92 FPR2 (0.62) FPR2
SCHEMBL2327724 0.91 FPR2 (0.63) FPR2CACNA1H
SCHEMBL2326649 0.90 FPR2 (0.64) FPR2
SCHEMBL2327005 0.88 FPR2 (0.66) FPR2CACNA1H
SCHEMBL2324343 0.87 FPR2 (0.65) FPR2
SCHEMBL2328435 0.83 FPR2 (0.65) FPR2CACNA1H
SCHEMBL2329232 0.82 FPR2 (0.62) FPR2
SCHEMBL2327126 0.81 FPR2 (0.63) FPR2
SCHEMBL2324623 0.81 FPR2 (0.62) FPR2
SCHEMBL2324482 0.81 FPR2 (0.66) FPR2CACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2225231-B1 AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2011-08-17 EP disclosed