Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.44 |
| ▸ | CCND1 | P24385 | 12/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 12/20 | 0.44 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19868280 | 0.83 | CCNE1 (0.61) | CDK2CCNE1CCND1CDK6CCNT1 | |
| SCHEMBL23340848 | 0.83 | BRD4 (0.44) | CDK2CCNE1CCND1CDK6BRD4 | |
| SCHEMBL23341176 | 0.81 | BRD4 (0.46) | CDK2CCNE1CCND1CDK6BRD4 | |
| SCHEMBL23340894 | 0.80 | BRD4 (0.45) | CDK2CCNE1CCND1CDK6BRD4 | |
| SCHEMBL23340901 | 0.78 | MAPK14 (0.49) | CDK2CCNE1CCND1CDK6BRD4 | |
| SCHEMBL19868152 | 0.75 | CCNE1 (0.56) | CDK2CCNE1CCND1CDK6CCNT1 | |
| SCHEMBL23341158 | 0.75 | MAPK8 (0.49) | CDK2CCNE1CCND1CDK6CCNT1 | |
| SCHEMBL19868170 | 0.74 | CCNE1 (0.60) | CDK2CCNE1CCND1CDK6CCNT1 | |
| SCHEMBL19868293 | 0.74 | CCNE1 (0.62) | CDK2CCNE1CCND1CDK6CCNT1 | |
| SCHEMBL23340820 | 0.73 | BRD4 (0.40) | CDK2CCNE1CCND1CDK6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497103-B1 | PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS | PFIZER (US) | 2021-05-05 | — | — | EP | disclosed |