Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331291 | 1.00 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL2336215 | 0.99 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL2340928 | 0.98 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL2334385 | 0.93 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL2341197 | 0.90 | ALDH1A1 (0.59) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL5522458 | 0.88 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5509267 | 0.88 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2339078 | 0.86 | HPGD (0.39) | ALDH1A1LMNASMN1; SMN2HSD17B10PSEN1 | |
| SCHEMBL2335244 | 0.85 | TP53 (0.44) | ALDH1A1LMNASMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL2339348 | 0.83 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374792-A1 | N-substituted benzene sulfonamides | Elan Pharmaceuticals Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| EP-2360142-A1 | N-substituted benzene sulfonamides | Elan Pharmaceuticals Inc. (US) | 2011-08-24 | — | — | EP | disclosed |