Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Difluprednate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.64 |
| ▸ | PGR | P06401 | 7/20 | 0.64 |
| ▸ | AR | P10275 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Difluprednate SCHEMBL5486757 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL14339608 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL19961204 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL9954379 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL5486753 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL1276671 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL4581 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL1276669 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL20769772 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR | |
| Difluprednate SCHEMBL4580 | 1.00 | HIF1A (1.00) | HIF1ALMNANPSR1CYP3A4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11000475-B2 | Ophthalmic solution of difluprednate | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11000475-B2 | Ophthalmic solution of difluprednate | NFKBIA, IKBKB, FGF1 | NR3C1 1090/4885HIF1A 1891/4885LMNA 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.