Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23344506 | 0.76 | PIK3CA (0.49) | PIK3CACCNA2CDK2CDK9CCNA1 | |
| SCHEMBL23344487 | 0.75 | MEN1 (0.51) | KDM4EHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL23344468 | 0.73 | NPC1 (0.56) | MAPTKDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL23344477 | 0.73 | MEN1 (0.53) | PIK3CATP53MAPTHPGDMEN1 | |
| SCHEMBL23344489 | 0.72 | PIK3CA (0.65) | PIK3CATP53MAPTCDK9KDM4E | |
| SCHEMBL23344442 | 0.71 | MEN1 (0.48) | MAPTABL1KDM4EHPGDLMNA | |
| SCHEMBL23344440 | 0.69 | SMN1; SMN2 (0.56) | TP53MAPTKDM4EHPGDLMNA | |
| SCHEMBL23344469 | 0.68 | HTT (0.53) | MAPTKDM4EHPGDLMNAGAA | |
| SCHEMBL23344502 | 0.67 | NPC1 (0.45) | MAPTKDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL7546481 | 0.65 | HPGD (0.62) | MAPTHPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117894-B2 | Pyridopyrazine compounds and uses thereof | CITY OF HOPE (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210139476-A1 | PYRIDOPYRAZINE COMPOUNDS AND USES THEREOF | NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS (GR) | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117894-B2 | Pyridopyrazine compounds and uses thereof | PDXK, DPYD, PNPO | PIK3CA 1262/4885TP53 1220/4885MAPT 2937/4885 |
| US-20210139476-A1 | PYRIDOPYRAZINE COMPOUNDS AND USES THEREOF | PDXK, DPYD, PNPO | PIK3CA 1262/4885TP53 1220/4885MAPT 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.