SCHEMBL2334463

SCHEMBL2334463

CC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3ccc4nc(C)ccc4c3)c2Cl)cn1

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8474928 0.85 BDKRB2 (0.74) BDKRB2
Fr-173657 SCHEMBL3718364 0.85 BDKRB2 (1.00) BDKRB2
Fr-173657 SCHEMBL1559539 0.85 BDKRB2 (1.00) BDKRB2
Fr-173657 SCHEMBL7246238 0.85 BDKRB2 (0.99) BDKRB2
Fr-173657 SCHEMBL7246230 0.85 BDKRB2 (0.99) BDKRB2
SCHEMBL2341928 0.84 BDKRB2 (0.60) BDKRB2
SCHEMBL8812166 0.82 BDKRB2 (0.90) BDKRB2
SCHEMBL6643303 0.82 BDKRB2 (0.68) BDKRB2
SCHEMBL6647296 0.82 BDKRB2 (0.68) BDKRB2
SCHEMBL6643301 0.82 BDKRB2 (0.68) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222275-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING BRADYKININ ANTAGONISTS AND HYALURONIC ACID, AND USES THEREOF LUSO FARMACO INST (IT) 2011-10-19 EP claimed
EP-1901775-B1 KININ ANTAGONISTS FOR TREATING BLADDER DYSFUNCTION JERINI AG (DE) 2011-08-24 EP claimed
EP-1739078-A1 Antagonists of C5a-receptor Jerini AG (DE) 2007-01-03 EP disclosed