Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14436539 | 0.87 | CYP1A2 (0.45) | CYP1A2CYP2C9P2RX7SCN10ASCN2A | |
| SCHEMBL23344783 | 0.86 | CYP1A2 (0.48) | CYP1A2CYP2C9P2RX7SCN10ASCN2A | |
| SCHEMBL3297100 | 0.82 | CYP1A2 (0.48) | CYP1A2CYP2C9P2RX7PIK3CAGBA1 | |
| SCHEMBL14803704 | 0.80 | CYP1A2 (0.48) | CYP1A2CYP2C9PIK3CAGBA1TRPV1 | |
| SCHEMBL13409587 | 0.79 | CYP1A2 (0.56) | CYP1A2CYP2C9P2RX7PIK3CASCN10A | |
| SCHEMBL3081290 | 0.79 | CYP1A2 (0.52) | CYP1A2CYP2C9P2RX7PIK3CASCN10A | |
| SCHEMBL15966076 | 0.77 | CYP1A2 (0.51) | CYP1A2CYP2C9PIK3CAGBA1PTK2 | |
| SCHEMBL23344762 | 0.77 | LRRK2 (0.39) | PIK3CAPIK3CDLRRK2MTORPIK3CG | |
| SCHEMBL3289804 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2C9P2RX7PIK3CASCN10A | |
| SCHEMBL5311868 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2C9P2RX7PIK3CASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | LIEBER INSTITUTE, INC | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | SCN8A, SCN5A, SCN2A | CYP1A2 3404/4885CYP2C9 4421/4885P2RX7 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.