Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14436539 | 0.98 | CYP1A2 (0.45) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL23344647 | 0.86 | CYP1A2 (0.45) | CYP1A2CYP2C9P2RX7SCN2ASCN10A | |
| SCHEMBL11859845 | 0.84 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL4305773 | 0.82 | CYP1A2 (0.55) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL22400199 | 0.80 | CYP1A2 (0.53) | CYP1A2CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL14614806 | 0.79 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL13028953 | 0.79 | KDM4E (0.37) | CYP1A2TSHRKDM4ELMNAALDH1A1 | |
| SCHEMBL326093 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL3063649 | 0.79 | CYP2C19 (0.51) | CYP1A2CYP2C9CYP2C19TSHRKDM4E | |
| SCHEMBL13026786 | 0.78 | ADRA2A (0.53) | CYP1A2CYP2C9CYP2C19TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | LIEBER INSTITUTE, INC | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139456-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 | SCN8A, SCN5A, SCN2A | CYP1A2 3404/4885CYP2C9 4421/4885CYP2C19 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.