⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11911969 | 0.81 | — | — | |
| SCHEMBL12389984 | 0.76 | — | — | |
| SCHEMBL18717717 | 0.76 | — | — | |
| SCHEMBL12553802 | 0.76 | — | — | |
| SCHEMBL13390167 | 0.75 | — | — | |
| SCHEMBL17465653 | 0.74 | — | — | |
| SCHEMBL19960785 | 0.70 | OPRM1 (0.31) | — | |
| SCHEMBL18849834 | 0.70 | — | — | |
| SCHEMBL12017450 | 0.69 | — | — | |
| SCHEMBL23345009 | 0.68 | GAA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2021-05-13 | — | — | US | disclosed |