Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.39 |
| ▸ | FEN1 | P39748 | 7/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17387527 | 0.89 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1ALOX5APFEN1OPRM1 | |
| SCHEMBL2509995 | 0.89 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL17387515 | 0.88 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALOX5APFEN1OPRM1 | |
| SCHEMBL2331903 | 0.86 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALOX5APFEN1OPRM1 | |
| SCHEMBL901807 | 0.85 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL2510626 | 0.83 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL2512188 | 0.83 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL17387506 | 0.83 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL2331279 | 0.83 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALOX5APFEN1 | |
| SCHEMBL17387508 | 0.83 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356110-B1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | claimed |
| EP-2356110-B1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |
| EP-2356110-A1 | QUINAZOLINAMIDE DERIVATIVES | Merck Patent GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010066324-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-17 | — | — | WO | disclosed |