Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902012 | 0.91 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1F10CYP1A2 | |
| SCHEMBL901443 | 0.90 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1F10CYP1A2 | |
| SCHEMBL902115 | 0.89 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1F10MEN1KMT2A | |
| SCHEMBL904180 | 0.88 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1CYP1A2LMNA | |
| SCHEMBL2334668 | 0.85 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL904169 | 0.84 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1F10 | |
| SCHEMBL904223 | 0.83 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL904181 | 0.83 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL904226 | 0.83 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL904034 | 0.83 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621919-A1 | PHENYLQUINAZOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041435-A1 | PHENYLQUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-04-05 | — | — | WO | disclosed |