Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 14/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728839 | 0.85 | CHRM4 (0.52) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL1728730 | 0.81 | MAOA (0.55) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL345057 | 0.81 | CHRM4 (0.57) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL15662802 | 0.80 | CHRM4 (0.50) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL346152 | 0.80 | CKS1B (0.39) | CHRM4LMNA | |
| SCHEMBL1730242 | 0.80 | CHRM4 (0.68) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL1728880 | 0.79 | CHRM4 (0.49) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL1711018 | 0.78 | CHRM4 (0.57) | CHRM4CHRM2CHRM1 | |
| SCHEMBL1728738 | 0.78 | CHRM4 (0.50) | CHRM4CHRM2CHRM1MAPT | |
| SCHEMBL14796867 | 0.78 | RET (0.48) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356108-B1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-15 | — | — | EP | disclosed |
| US-8716289-B2 | Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2014-05-06 | — | — | US | disclosed |
| EP-2356108-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055267-A1 | CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-05-20 | — | — | WO | disclosed |