SCHEMBL2335006

SCHEMBL2335006

Clc1cccc([Si](Cl)(Cl)Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.44
ALDH1A1 P00352 3/20 0.44
PNMT P11086 1/20 0.39
CHRM5 P08912 1/20 0.38
TAAR1 Q96RJ0 1/20 0.37
PARP1 P09874 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NOTUM Q6P988 1/20 0.36
NPC1 O15118 1/20 0.36
TP53 P04637 1/20 0.36
NFKB1 P19838 1/20 0.36
RAB9A P51151 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ALOX5 P09917 1/20 0.35
MGLL Q99685 1/20 0.35
HTR3E A5X5Y0 1/20 0.35
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17966523 0.84 TSHR (0.44) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL31465211 0.84 TSHR (0.44) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL17966510 0.84 TSHR (0.44) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL16714016 0.83
SCHEMBL23532361 0.81 TSHR (0.46) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL22318993 0.80 TSHR (0.41) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL21196889 0.80 TSHR (0.41) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL31064938 0.78 TSHR (0.43) TSHRALDH1A1PNMTCHRM5NPC1
SCHEMBL17937786 0.77 TSHR (0.42) TSHRALDH1A1PNMTCHRM5TAAR1
SCHEMBL9486124 0.77 TSHR (0.42) TSHRALDH1A1PNMTCHRM5TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107223127-B Method for producing organohalosilanes 美国陶氏有机硅公司 2020-09-11 CN disclosed
EP-3253770-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-09-02 EP disclosed
EP-3253771-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-08-12 EP disclosed
US-10183958-B2 Method of producing organohalosilanes DOW SILICONES CORPORATION (US) 2019-01-22 US disclosed
US-20180105542-A1 Method Of Producing Organohalosilanes DOW SILICONES CORPORATION 2018-04-19 US disclosed
US-9908903-B2 Method of producing organohalosilanes DOW CORNING CORPORATION (US) 2018-03-06 US disclosed
US-20170369514-A1 Method Of Producing Organohalosilanes DOW SILICONES CORPORATION 2017-12-28 US disclosed
EP-3260515-A1 POLISHING COMPOSITION Fujimi Incorporated (JP) 2017-12-27 EP disclosed
US-20160288289-A1 POLISHING COMPOSITION FUJIMI INCORPORATED (JP) 2016-10-06 US disclosed
WO-2016126804-A1 METHOD OF PRODUCING ORGANOHALOSILANES DOW CORNING CORPORATION (US) 2016-08-11 WO disclosed
WO-2016126808-A1 METHOD OF PRODUCING ORGANOHALOSILANES DOW CORNING CORPORATION (US) 2016-08-11 WO disclosed
EP-3048152-A1 POLISHING COMPOSITION Fujimi Incorporated (JP) 2016-07-27 EP disclosed
CN-105555901-A Polishing composition FUJIMI INC 2016-05-04 CN disclosed
WO-2016016042-A1 AGROCHEMICAL SUSPOEMULSION COMPRISING HYDROPHOBIC MODIFIED SILICA PARTICLES BASF SE (DE) 2016-02-04 WO disclosed
WO-2016008696-A1 AGROCHEMICAL OIL-IN-WATER EMULSION COMPRISING SILICA PARTICLES AND WATER-SOLUBLE NONIONIC EMULSIFIER BASF SE (DE) 2016-01-21 WO disclosed
US-8258234-B2 Process for preparing an aqueous composite-particle dispersion BASF SE (DE) 2012-09-04 US disclosed
EP-2205644-B1 METHOD FOR PRODUCING AN AQUEOUS COMPOSITE-PARTICLE DISPERSION BASF SE (DE) 2011-08-17 EP disclosed
US-20100216942-A1 PROCESS FOR PREPARING AN AQUEOUS COMPOSITE-PARTICLE DISPERSION BASF SE (DE) 2010-08-26 US disclosed
US-7463400-B1 Electrochromic display device FUJI XEROX CO., LTD. (JP) 2008-12-09 US disclosed
US-6284365-B1 FOR CONTROLLING PHYSICAL PROPERTIES OF SURFACE AND INTERFACE OF SOLID ARTICLE SUCH AS WETTABILITY, ADHESIVE PROPERTY, SURFACE ENERGY, DISPERSABILITY, CHEMICAL RESISTANCE FUJI XEROX CO., LTD. (JP) 2001-09-04 US disclosed