Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335370 | 1.00 | ADAMTS5 (0.52) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2332910 | 0.86 | ADAMTS5 (0.51) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2332915 | 0.86 | ADAMTS5 (0.51) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2335682 | 0.85 | ADAMTS5 (0.50) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2337938 | 0.85 | PSEN1 (0.55) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2335609 | 0.84 | ADAMTS5 (0.49) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2332243 | 0.83 | ADAMTS5 (0.48) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2335348 | 0.81 | ADAMTS5 (0.49) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2333175 | 0.81 | ADAMTS5 (0.49) | ADAMTS5ALDH1A1TP53GAAPSEN1 | |
| SCHEMBL2336537 | 0.81 | PSEN1 (0.51) | ADAMTS5ALDH1A1TP53GAAPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270902-A1 | N-substituted benzene sulfonamides | ELAN PHARMACEUTICALS, INC. (US) | 2012-10-25 | — | — | US | claimed |
| EP-2374792-A1 | N-substituted benzene sulfonamides | Elan Pharmaceuticals Inc. (US) | 2011-10-12 | — | — | EP | claimed |
| US-20050245573-A1 | N-substituted benzene sulfonamides | ELAN PHARMACEUTICALS, INC. | 2005-11-03 | — | — | US | claimed |
| US-20120270902-A1 | N-substituted benzene sulfonamides | ELAN PHARMACEUTICALS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-8193389-B2 | N-substituted benzene sulfonamides | ELAN PHARMACEUTICALS, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| EP-2374792-A1 | N-substituted benzene sulfonamides | Elan Pharmaceuticals Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| EP-2360142-A1 | N-substituted benzene sulfonamides | Elan Pharmaceuticals Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20050245573-A1 | N-substituted benzene sulfonamides | ELAN PHARMACEUTICALS, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245573-A1 | N-substituted benzene sulfonamides | PSEN1, PSEN2, BCHE | ADAMTS5 4395/4885ALDH1A1 665/4885TP53 224/4885 |
| US-20120270902-A1 | N-substituted benzene sulfonamides | PSEN1, PSEN2, BCHE | ADAMTS5 4395/4885ALDH1A1 665/4885TP53 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.