Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 6/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.37 |
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355377 | 0.86 | KDM4E (0.44) | KDM4EMAPTTNKSPARP2PARP1 | |
| SCHEMBL23355454 | 0.83 | SMN1; SMN2 (0.39) | KDM4EMAPTALDH1A1DHODHLCLAT1 | |
| SCHEMBL23368199 | 0.81 | KDM4E (0.40) | KDM4EMAPTTNKSPARP2PARP1 | |
| SCHEMBL30203050 | 0.81 | KDM4E (0.40) | KDM4EMAPTTNKSPARP2PARP1 | |
| Trifluoroacetic Acid SCHEMBL23355399 | 0.81 | KDM4E (0.45) | KDM4EHDAC3CYP2C9HDAC1HDAC6 | |
| SCHEMBL23368034 | 0.77 | KDM4E (0.50) | KDM4EMAPTBACE1BACE2ALDH1A1 | |
| SCHEMBL23355465 | 0.75 | GSK3B (0.37) | KDM4EHDAC3HDAC1HDAC6DHODH | |
| SCHEMBL23355403 | 0.74 | KDM4E (0.40) | KDM4EHDAC1HDAC6ALDH1A1DHODH | |
| SCHEMBL21612784 | 0.72 | KDM4E (0.47) | KDM4EMAPTTNKSPARP2PARP1 | |
| SCHEMBL23355373 | 0.71 | KDM4E (0.45) | KDM4EMAPTALDH1A1DHODHLCLAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822263-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-05-19 | — | — | EP | disclosed |