Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.31 |
| ▸ | PPARD | Q03181 | 3/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21612851 | 0.87 | SCN9A (0.35) | SCN9APRSS1TMPRSS15 | |
| SCHEMBL23355321 | 0.77 | GCK (0.32) | PRSS1TMPRSS15ICAM1SELEGCK | |
| SCHEMBL28527025 | 0.76 | — | — | |
| SCHEMBL28523464 | 0.75 | MEN1 (0.38) | FFAR1PPARDALDH1A1SCN4A | |
| SCHEMBL23355323 | 0.75 | MEN1 (0.40) | PPARDALDH1A1 | |
| SCHEMBL23355478 | 0.72 | MAPT (0.34) | SCN9A | |
| SCHEMBL23355451 | 0.72 | CYP17A1 (0.42) | SCN9A | |
| SCHEMBL23368138 | 0.71 | HSD17B10 (0.47) | SCN9AGAAKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL30203152 | 0.71 | HSD17B10 (0.46) | SCN9AGAAKDM4EALDH1A1HPGD | |
| SCHEMBL16399169 | 0.69 | NPC1 (0.44) | SCN9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822263-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-05-19 | — | — | EP | disclosed |
| CN-112334460-A | Biaryl ether type quinazoline derivative | 第一三共株式会社 | 2021-02-05 | — | — | CN | disclosed |