Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21612850 | 0.86 | MAPT (0.33) | MAPTATRGPR119BACE1BACE2 | |
| SCHEMBL24926748 | 0.84 | BACE1 (0.36) | MAPTATRGPR119BACE1BACE2 | |
| SCHEMBL23355350 | 0.82 | MAPK14 (0.35) | MAPTSMO | |
| SCHEMBL21612849 | 0.81 | MAPT (0.33) | MAPTATRBACE1BACE2 | |
| SCHEMBL28537439 | 0.81 | ATR (0.32) | ATRBACE1BACE2CA1CA2 | |
| SCHEMBL24926751 | 0.78 | BRAF (0.40) | MAPTSMO | |
| SCHEMBL23355446 | 0.72 | SCN9A (0.36) | SCN9A | |
| SCHEMBL23355355 | 0.72 | LRRK2 (0.32) | — | |
| SCHEMBL23355323 | 0.72 | MEN1 (0.40) | — | |
| SCHEMBL28523464 | 0.72 | MEN1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822263-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-05-19 | — | — | EP | disclosed |
| CN-112334460-A | Biaryl ether type quinazoline derivative | 第一三共株式会社 | 2021-02-05 | — | — | CN | disclosed |