Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.63 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.60 |
| ▸ | TLK2 | Q86UE8 | 12/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064437 | 0.83 | TLK2 (0.67) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL20401696 | 0.83 | TLK2 (0.67) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL12727794 | 0.83 | TLK2 (0.67) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL29264971 | 0.77 | NTRK1 (1.00) | NTRK1NTRK3PDPK1TLK2 | |
| SCHEMBL29264975 | 0.77 | NTRK1 (1.00) | NTRK1NTRK3PDPK1TLK2 | |
| SCHEMBL19709650 | 0.77 | TLK2 (0.68) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL9921923 | 0.77 | TLK2 (0.72) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL17679290 | 0.75 | PDPK1 (1.00) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL23369222 | 0.75 | PDPK1 (1.00) | NTRK1NTRK3PDPK1TLK2CDK5 | |
| SCHEMBL23356454 | 0.75 | NTRK1 (0.62) | NTRK1PDPK1RETMAPK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204002-B1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TUMORS | INTERNATIONAL SOC FOR DRUG DEVELOPMENT S R L (IT) | 2021-05-19 | — | — | EP | claimed |