Bromide

Bromide

SCHEMBL2335688

C[N+]1(C)CC[C@H](OC(=O)Cc2cccc(C3CCCC3)c2O)C1.[Br-]

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 known ✓ P20309 15/20 0.43
CHRM2 known ✓ P08172 10/20 0.43
CHRM4 known ✓ P08173 3/20 0.43
CHRM5 known ✓ P08912 3/20 0.43
CHRM1 known ✓ P11229 3/20 0.43
KCNH2 Q12809 2/20 0.43
HRH1 P35367 1/20 0.43
HTR2B P41595 1/20 0.43
SLC22A1 O15245 1/20 0.38
LMNA P02545 3/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 1/20 0.37
SLC6A4 P31645 1/20 0.37
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
THRB P10828 2/20 0.34
BLM P54132 2/20 0.34
PMP22 Q01453 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL417945 1.00 CHRM3 (0.43) CHRM3CHRM2CHRM4CHRM5CHRM1
Bromide SCHEMBL1996228 1.00 CHRM3 (0.43) CHRM3CHRM2CHRM4CHRM5CHRM1
Bromide SCHEMBL5395427 0.99 CHRM3 (0.43) CHRM3CHRM2CHRM4CHRM5CHRM1
Bromide SCHEMBL5388585 0.99 CHRM3 (0.43) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL1707214 0.99 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL2340421 0.99 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL5473748 0.99 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL8449813 0.98 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
Iodide SCHEMBL5386794 0.98 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL7142072 0.98 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1755590-B1 COMBINATION OF GLYCOPYRROLATE AND A BETA2 ADRENOCEPTOR AGONIST NOVARTIS AG (CH) 2011-08-24 EP claimed