Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.45 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.45 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371266 | 0.98 | HRH3 (0.51) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL1277024 | 0.96 | HRH3 (0.54) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| Iodide SCHEMBL2333886 | 0.94 | HRH3 (0.52) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL25009132 | 0.90 | HRH3 (0.58) | HRH3ALDH1A1CYP2D6MEN1CYP1A2 | |
| SCHEMBL20332383 | 0.90 | HRH3 (0.49) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL2680332 | 0.90 | HRH3 (0.48) | HRH3ALDH1A1CYP2D6MEN1CYP1A2 | |
| SCHEMBL502016 | 0.90 | HRH3 (0.48) | HRH3ALDH1A1CYP2D6MEN1CYP1A2 | |
| SCHEMBL501715 | 0.90 | HRH3 (0.48) | HRH3ALDH1A1CYP2D6MEN1CYP1A2 | |
| SCHEMBL20332771 | 0.88 | HRH3 (0.51) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL501637 | 0.88 | HRH3 (0.52) | HRH3ALDH1A1CYP2D6MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534134-A1 | LOW VISCOSITY IONIC LIQUIDS | Invista Technologies S.à.r.l. (CH) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100232-A1 | LOW VISCOSITY IONIC LIQUIDS | INVISTA TECHNOLOGIES S.A R.L. (CH) | 2011-08-18 | — | — | WO | disclosed |