Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 16/20 | 0.63 |
| ▸ | LONP1 | P36776 | 11/20 | 0.63 |
| ▸ | PSMB8 | P28062 | 11/20 | 0.63 |
| ▸ | PSMB9 | P28065 | 11/20 | 0.63 |
| ▸ | PSMB6 | P28072 | 11/20 | 0.63 |
| ▸ | PSMB10 | P40306 | 11/20 | 0.63 |
| ▸ | PSMB11 | A5LHX3 | 10/20 | 0.63 |
| ▸ | PSMA7 | O14818 | 10/20 | 0.63 |
| ▸ | PSMB1 | P20618 | 10/20 | 0.63 |
| ▸ | PSMA1 | P25786 | 10/20 | 0.63 |
| ▸ | PSMA2 | P25787 | 10/20 | 0.63 |
| ▸ | PSMA3 | P25788 | 10/20 | 0.63 |
| ▸ | PSMA4 | P25789 | 10/20 | 0.63 |
| ▸ | PSMA5 | P28066 | 10/20 | 0.63 |
| ▸ | PSMB4 | P28070 | 10/20 | 0.63 |
| ▸ | PSMB3 | P49720 | 10/20 | 0.63 |
| ▸ | PSMB2 | P49721 | 10/20 | 0.63 |
| ▸ | PSMA6 | P60900 | 10/20 | 0.63 |
| ▸ | PSMA8 | Q8TAA3 | 10/20 | 0.63 |
| ▸ | PSMB7 | Q99436 | 10/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL1041561 | 1.00 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| D-Leucine SCHEMBL2338392 | 1.00 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL21955431 | 1.00 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL19712512 | 0.97 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL1406108 | 0.97 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL2931152 | 0.94 | PSMB5 (0.68) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL28490857 | 0.94 | PSMB5 (0.68) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL20496418 | 0.90 | PSMB5 (0.58) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL2344285 | 0.88 | PSMB5 (0.60) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL2126381 | 0.87 | PSMB5 (0.72) | PSMB5LONP1PSMB8PSMB9PSMB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008721-B1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-4008721-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | Millennium Pharmaceuticals, Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| EP-3385267-B1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2021-09-29 | — | — | EP | disclosed |
| EP-2377869-B1 | Synthesis of Bortezomib | MILLENNIUM PHARM INC (US) | 2014-01-29 | — | — | EP | disclosed |
| US-8283467-B2 | Synthesis of boronic ester and acid compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| EP-2377869-A1 | Synthesis of Bortezomib | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-19 | — | — | EP | disclosed |
| EP-1756121-B1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2011-08-24 | — | — | EP | disclosed |
| US-7714159-B2 | contacting the boronate complex of formula with Lewis acid catalyst in presence of a coordinating ether solvent having low miscibililty in water | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | disclosed |