Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS7 | Q9UKP4 | 9/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 10/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.34 |
| ▸ | MMP12 | P39900 | 7/20 | 0.34 |
| ▸ | MMP2 | P08253 | 6/20 | 0.34 |
| ▸ | MMP3 | P08254 | 6/20 | 0.34 |
| ▸ | MMP13 | P45452 | 6/20 | 0.34 |
| ▸ | MMP14 | P50281 | 6/20 | 0.34 |
| ▸ | MMP8 | P22894 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23367035 | 0.83 | — | — | |
| SCHEMBL23366977 | 0.83 | ADAMTS7 (0.51) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL24182506 | 0.83 | ADAMTS7 (0.51) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23366904 | 0.77 | ADAMTS7 (0.38) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23366881 | 0.71 | GAA (0.35) | ADAMTS5MMP2 | |
| SCHEMBL23366861 | 0.71 | GAA (0.32) | ADAMTS5MMP2 | |
| SCHEMBL23367467 | 0.68 | ADAMTS7 (0.39) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL23367377 | 0.67 | ADAMTS7 (0.35) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL14466249 | 0.66 | ADAMTS7 (0.45) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 | |
| SCHEMBL24182492 | 0.62 | ADAMTS7 (0.42) | ADAMTS7ADAMTS5ADAMTS4MMP12MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822268-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2021-05-19 | — | — | EP | disclosed |