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Sugi Predict / Targets / ADAMTS7

ADAMTS7

A disintegrin and metalloproteinase with thrombospondin motifs 7 · Q9UKP4 · ADAMTS7 on Sugi Atlas →

2,384 patent compounds predicted against ADAMTS7, 1,412 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL23353980 SCHEMBL23353980 1.00 20/20
SCHEMBL23353983 SCHEMBL23353983 1.00 20/20
SCHEMBL23354007 SCHEMBL23354007 1.00 20/20
SCHEMBL23353974 SCHEMBL23353974 0.81 20/20
SCHEMBL23354068 SCHEMBL23354068 0.81 20/20
SCHEMBL23353991 SCHEMBL23353991 0.80 20/20
SCHEMBL23354022 SCHEMBL23354022 0.80 20/20
SCHEMBL23354181 SCHEMBL23354181 0.80 20/20
SCHEMBL23354138 SCHEMBL23354138 0.79 20/20
SCHEMBL23354011 SCHEMBL23354011 0.78 20/20
SCHEMBL23354175 SCHEMBL23354175 0.77 20/20
SCHEMBL23354140 SCHEMBL23354140 0.75 20/20
SCHEMBL23354051 SCHEMBL23354051 0.74 20/20
SCHEMBL23354075 SCHEMBL23354075 0.71 20/20
SCHEMBL23354161 SCHEMBL23354161 0.70 20/20
SCHEMBL23354077 SCHEMBL23354077 0.70 20/20
SCHEMBL23354082 SCHEMBL23354082 0.70 20/20
SCHEMBL23353994 SCHEMBL23353994 0.61 20/20
SCHEMBL23354012 SCHEMBL23354012 0.60 20/20
SCHEMBL23353969 SCHEMBL23353969 0.69 19/20

Clinical trials — most relevant to ADAMTS7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura PHASE4WITHDRAWN
Aspirin for Prophylaxis of TTP PHASE2/PHASE3NOT_YET_RECRUITING
PRP in ACLR to Prevent PTOA PHASE3RECRUITING
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast PHASE2COMPLETED
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint PHASE2COMPLETED
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP) PHASE2COMPLETED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer PHASE2COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP) PHASE1COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement PHASE1COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO) nanUNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction nanCOMPLETED
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia nanUNKNOWN
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer nanCOMPLETED
Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura nanACTIVE_NOT_RECRUITING
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome) nanRECRUITING
ADAMTS13 in Thrombotic Thrombocytopenic Purpura nanCOMPLETED
Exercise-related Irisin on Inflammation and Pain nanUNKNOWN
Apoptotic Changes in Gingiva Caused by Smoking nanCOMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects nanAVAILABLE
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial nanCOMPLETED
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI) nanUNKNOWN
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence nanWITHDRAWN
Screening of TMA Patients für ADAMTS13 Activity (Adamscreen) nanUNKNOWN
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma nanUNKNOWN
LRP1 and Colon Cancer nanUNKNOWN
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma nanCOMPLETED
Peri-implantitis and MMP-8 nanCOMPLETED
Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease nanNOT_YET_RECRUITING
Biomarkers in Post Thrombotic Syndrome nanCOMPLETED
Elevated Plasma Levels of TIMP-1 in Patients With Rotator Cuff Tear nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ADAMTS7 binder may also engage these)

ProteinNameSimilarity
Q9H324 — 0.997 Q9H324 →
P58459 — 0.997 P58459 →
O95450 — 0.997 O95450 →
Q8WXS8 — 0.997 Q8WXS8 →
Q8TE58 — 0.996 Q8TE58 →
Q68SA9 — 0.996 Q68SA9 →
Q8BNJ2 — 0.995 Q8BNJ2 →
P59384 — 0.995 P59384 →
Q9TT93 — 0.994 Q9TT93 →
ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 0.994 landscape →
Q1EHB3 — 0.994 Q1EHB3 →
P59511 — 0.994 P59511 →
Q8C9W3 — 0.992 Q8C9W3 →
P79331 — 0.992 P79331 →
Q8TE57 — 0.990 Q8TE57 →
P57110 — 0.990 P57110 →
P97857 — 0.990 P97857 →
Q69Z28 — 0.989 Q69Z28 →
ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 0.989 landscape →
Q9WUQ1 — 0.988 Q9WUQ1 →
Q9ESP7 — 0.988 Q9ESP7 →
Q4VC17 — 0.987 Q4VC17 →
Q5RFQ8 — 0.987 Q5RFQ8 →
P59510 — 0.985 P59510 →
ADAM8 Disintegrin and metalloproteinase domain-containing protein 8 0.984 landscape →
Q8TE56 — 0.984 Q8TE56 →
Q9R001 — 0.983 Q9R001 →
Q811B3 — 0.983 Q811B3 →
Q05910 — 0.983 Q05910 →
ADAMTS4 A disintegrin and metalloproteinase with thrombospondin motifs 4 0.983 landscape →