Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | TRHR | P34981 | 6/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rovatirelin SCHEMBL20811796 | 0.84 | DPP4 (0.42) | DPP4DPP8DPP9TRHRCAPN1 | |
| Rovatirelin SCHEMBL14306794 | 0.84 | DPP4 (0.42) | DPP4DPP8DPP9TRHRCAPN1 | |
| Rovatirelin SCHEMBL14280927 | 0.84 | DPP4 (0.42) | DPP4DPP8DPP9TRHRCAPN1 | |
| Rovatirelin SCHEMBL5176249 | 0.83 | DPP4 (0.43) | DPP4DPP8DPP9TRHRCAPN1 | |
| SCHEMBL5734227 | 0.78 | DPP4 (0.53) | DPP4DPP8DPP9TRHR | |
| SCHEMBL20787861 | 0.76 | SCN9A (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL20787862 | 0.76 | SCN9A (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL14280924 | 0.74 | DPP4 (0.71) | DPP4DPP8DPP9 | |
| SCHEMBL14306793 | 0.74 | DPP4 (0.71) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5735691 | 0.73 | TRHR (0.67) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3315128-B1 | DOSING REGIMEN OF ROVATIRELIN FOR ATAXIA ASSOCIATED WITH SPINOCEREBELLAR DEGENERATION | SHIONOGI & CO (JP) | 2021-05-19 | — | — | EP | disclosed |