TRHR

Thyrotropin-releasing hormone receptor · P34981 · TRHR on Sugi Atlas →

1,207 patent compounds predicted against TRHR, 515 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Protirelin (SCHEMBL33419)	1.00	6/20
Protirelin (SCHEMBL10087855)	1.00	6/20
Protirelin (SCHEMBL10087946)	1.00	6/20
Protirelin (SCHEMBL16091769)	1.00	6/20
Protirelin (SCHEMBL4406163)	0.93	6/20
SCHEMBL11929118	0.92	6/20
Protirelin (SCHEMBL1007386)	0.91	6/20
SCHEMBL29539733	0.85	6/20
Azetirelin (SCHEMBL195158)	0.85	6/20
SCHEMBL16072685	0.84	6/20
SCHEMBL16088505	0.84	6/20
Protirelin (SCHEMBL11309963)	0.84	6/20
SCHEMBL10589322	0.76	6/20
SCHEMBL11925275	0.75	6/20
SCHEMBL17429486	0.74	6/20
SCHEMBL30493140	0.73	6/20
Protirelin (SCHEMBL2182035)	0.71	6/20
Protirelin (SCHEMBL8364920)	0.71	6/20
Protirelin (SCHEMBL11798811)	0.71	6/20
Protirelin (SCHEMBL14280929)	0.71	6/20

Clinical trials — most relevant to TRHR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Contributions to Hypertension With Androgen Deprivation Therapy	PHASE4	COMPLETED
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE)	PHASE4	COMPLETED
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)	PHASE2/PHASE3	UNKNOWN
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency	PHASE3	COMPLETED
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)	PHASE3	RECRUITING
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities	PHASE2	COMPLETED
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia	PHASE2	COMPLETED
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids.	PHASE2	COMPLETED
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers	PHASE2	COMPLETED
Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy	PHASE1/PHASE2	RECRUITING
Tofacitinib for Glucocorticoid-Resistant Moderate-to-Severe Thyroid Eye Disease	PHASE2	RECRUITING
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer	PHASE1	WITHDRAWN
A Study of IBI3031 in Participants With Thyroid Eye Disease	PHASE1	NOT_YET_RECRUITING
Natural History of Thyroid Function Disorders	nan	RECRUITING
Phase I/II Study of Neuroendocrine Dysfunction in Patients With Closed Head Injuries	nan	UNKNOWN
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly	nan	COMPLETED
Quality of Life Among Egyptian Hypothyroid Patients	nan	UNKNOWN
Register for Patients With Thyroid Hormone Resistance.	nan	RECRUITING
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism	nan	UNKNOWN
TSH Receptor Mutations Among a Consanguineous Community	nan	COMPLETED
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment	nan	COMPLETED
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects	nan	RECRUITING
Impact of Thyroid Hormones on Human Glucose and Energy Metabolism	nan	RECRUITING
Rubus Sanctus (Wild Blackberry) Root Extract as a Dietary Supplement for Graves' Disease	nan	COMPLETED
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine	nan	RECRUITING
Baselines in Reproductive Disorders	nan	UNKNOWN
HIFU vs RAI in the Relapsed Graves' Disease	nan	COMPLETED
Thyroid Function in Liver Cirrhosis: Is it Affected?	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TRHR binder may also engage these)

Protein	Name	Similarity
Q28596	—	1.000	Q28596 →
O46639	—	1.000	O46639 →
P21761	—	1.000	P21761 →
O93603	—	1.000	O93603 →
Q01717	—	1.000	Q01717 →
BRS3	Bombesin receptor subtype-3	0.983	landscape →
O54798	—	0.983	O54798 →
P35371	—	0.981	P35371 →
Q8K418	—	0.981	Q8K418 →
Q6H2Y3	—	0.980	Q6H2Y3 →
P47751	—	0.979	P47751 →
O97967	—	0.979	O97967 →
Q8BZP8	—	0.978	Q8BZP8 →
Q56H79	—	0.976	Q56H79 →
Q7T3Q7	—	0.973	Q7T3Q7 →
Q8ITC9	—	0.973	Q8ITC9 →
NPY2R	Neuropeptide Y receptor type 2	0.972	landscape →
P0C0L6	—	0.972	P0C0L6 →
A1ZAX0	—	0.971	A1ZAX0 →
P79113	—	0.971	P79113 →
NPSR1	Neuropeptide S receptor	0.971	landscape →
Q9GK74	—	0.971	Q9GK74 →
O02835	—	0.970	O02835 →
O62809	—	0.970	O62809 →
Q5IS62	—	0.970	Q5IS62 →
Q924H0	—	0.970	Q924H0 →
Q8K458	—	0.969	Q8K458 →
Q8ITC7	—	0.969	Q8ITC7 →
Q5U431	—	0.969	Q5U431 →
PROKR2	Prokineticin receptor 2	0.969	landscape →