Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23368379 | 0.90 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368380 | 0.87 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368381 | 0.85 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368382 | 0.85 | TSHR (0.51) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368310 | 0.82 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368299 | 0.81 | POLB (0.39) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368341 | 0.81 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23368311 | 0.80 | NPC1 (0.55) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL31602336 | 0.75 | KMO (0.56) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL17269342 | 0.71 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411411-B1 | 1H-INDAZOLE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS FACTOR D INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ABERRANT COMPLEMENT SYSTEM ACTIVITY, SUCH AS E.G. IMMUNOLOGICAL DISORDERS | BIOCRYST PHARM INC (US) | 2021-05-19 | — | — | EP | disclosed |